Brain Abnormalities
in treatment-resistant depression!
My first reaction is to scoff and say “Well, imagine that!” I can perform such utterances due to the fact that I actually do suffer from treatment-resistant depression. And there is no doubt in my mind that my mind functions differently than many people I have known.
WHAT IS TREATMENT-RESISTANT DEPRESSION?
Treatment-resistant depression is defined as the failure to respond to at least two different antidepressant treatments administered at adequate doses and durations.
“Treatment-resistant depression has a signature in the firing pattern of neurons in the brain, especially during an emotional task. We see the brain being perhaps overly sensitive to negative emotional information in depression patients, and we see evidence of increased top-down inhibition from a moderating brain region that may explain the abnormality. Further, we see after therapeutic brain stimulation, this pattern is…
